Invention Grant
- Patent Title: Compositions and methods for reducing oxidative damage
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Application No.: US15385416Application Date: 2016-12-20
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Publication No.: US10195225B2Publication Date: 2019-02-05
- Inventor: Tongalp H. Tezel , Andrea S. Gobin , Martin G. O'Toole
- Applicant: University of Louisville Research Foundation, Inc.
- Applicant Address: US CA Palo Alto
- Assignee: PromiSight
- Current Assignee: PromiSight
- Current Assignee Address: US CA Palo Alto
- Agency: Bozicevic, Field & Francis LLP
- Agent Glenn J. Foulds
- Main IPC: C08F2/46
- IPC: C08F2/46 ; C08F2/50 ; C08G61/04 ; A61K31/7016 ; C08L1/28 ; C08L5/02 ; C08L5/08 ; C08L5/10 ; A61K9/00 ; A61K47/32 ; A61K47/38 ; C08L33/14 ; A61F9/00

Abstract:
Polymeric compositions are provided that include a poly(ethylene glycol), a viscoelastic polymer, and an antioxidant, where, in polymerized form, the compositions have a refractive index of about 1.30 to about 1.40. Methods of synthesizing the compositions are also provided and include the steps of heating an amount of water; adding a buffering agent to the water to form a buffer solution; mixing a poly(ethylene glycol) and a viscoelastic polymer into the buffer solution to form a reactive mixture; adding a plurality of antioxidant particles to the reactive mixture; and removing suspended gas bubbles from the reactive mixture. Methods of preventing oxidative damage to an eye lens of a subject are further provided and include administering the foregoing polymeric compositions to the eye lens of the subject.
Public/Granted literature
- US20180153917A1 COMPOSITIONS AND METHODS FOR REDUCING OXIDATIVE DAMAGE Public/Granted day:2018-06-07
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