Invention Grant
- Patent Title: Generation of human induced pluripotent stem cells using nucleic acid sequences that inhibit Δ-NP63 and DGCR8
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Application No.: US14394882Application Date: 2013-04-18
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Publication No.: US10195229B2Publication Date: 2019-02-05
- Inventor: Elsa R. Flores , Deepavali Chakravarti
- Applicant: Elsa R. Flores , Deepavali Chakravarti
- Applicant Address: US FL Lutz US TX Pearland
- Assignee: Elsa R. Flores,Deepavali Chakravarti
- Current Assignee: Elsa R. Flores,Deepavali Chakravarti
- Current Assignee Address: US FL Lutz US TX Pearland
- Agency: Parker Highlander PLLC
- International Application: PCT/US2013/037186 WO 20130418
- International Announcement: WO2013/158890 WO 20131024
- Main IPC: A61K35/12
- IPC: A61K35/12 ; C12N5/074 ; C12N15/113
Abstract:
The present invention generally concerns particular methods and compositions for generation of induced pluripotent stem cells. In particular aspects, induced pluripotent stem cells are generated from adult somatic cells following downregulation of a particular gene of interest. In some embodiments, induced pluripotent stem cells are generated from keratinocytes upon downregulation of ΔNp63 or DGCR8.
Public/Granted literature
- US20150157662A1 GENERATION OF INDUCED PLURIPOTENT STEM CELLS BY MODULATION OF DELTA-NP63 OR DCGR8 Public/Granted day:2015-06-11
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