Invention Grant
- Patent Title: GLP-1 derivatives and uses thereof
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Application No.: US14897738Application Date: 2014-06-19
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Publication No.: US10195255B2Publication Date: 2019-02-05
- Inventor: Steffen Reedtz-Runge , Per Sauerberg , Jacob Kofoed , Ingrid Pettersson , Christian W. Tornoee
- Applicant: Novo Nordisk A/S
- Applicant Address: DK Bagsvaerd
- Assignee: Novo Nordisk A/S
- Current Assignee: Novo Nordisk A/S
- Current Assignee Address: DK Bagsvaerd
- Agent Jianjie Hu
- Priority: EP13173068 20130620; EP13175092 20130704
- International Application: PCT/EP2014/062952 WO 20140619
- International Announcement: WO2014/202727 WO 20141224
- Main IPC: A61K47/54
- IPC: A61K47/54 ; A61K47/56 ; A61K47/60 ; A61K38/26 ; C07K14/605

Abstract:
The invention relates to a derivative of a GLP-1 analogue, optionally C-terminally extended, which derivative comprises a first and a second protracting moiety in the form of a C20 or C22 diacid radical, a bis-amino branched linker, and a first and a second further linker each comprising an OEG-like linker element; wherein these elements are interconnected via amide bonds and attached to a Lys residue of the GLP-1 analogue. The invention also relates to intermediate products in the form of novel GLP-1 analogues incorporated in the derivatives of the invention, as well pharmaceutical compositions and medical uses of the derivatives. The derivatives have very long half-lives while maintaining a satisfactory potency, which makes them potentially suitable for once-monthly administration.
Public/Granted literature
- US20160143998A1 GLP-1 Derivatives and Uses Thereof Public/Granted day:2016-05-26
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