Invention Grant
- Patent Title: Process for purifying 1,4,7,10-tetra-azacyclododecane-1,4,7,10-tetraacetic acid
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Application No.: US15116263Application Date: 2015-02-02
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Publication No.: US10195295B2Publication Date: 2019-02-05
- Inventor: Diederik Buffel , Xavier Boi , Judith Pype
- Applicant: T2Pharma GmbH
- Applicant Address: DE Weimar
- Assignee: T2PHARMA GMBH
- Current Assignee: T2PHARMA GMBH
- Current Assignee Address: DE Weimar
- Agency: Hoffmann & Baron, LLP
- Priority: EP14154106 20140206
- International Application: PCT/EP2015/052033 WO 20150202
- International Announcement: WO2015/117911 WO 20150813
- Main IPC: A61K49/00
- IPC: A61K49/00 ; A61K47/18 ; A61K49/10 ; C07D257/02 ; B01D61/02 ; C07D295/15 ; C07F5/00

Abstract:
A process for purifying a compound of formula 1, includes the following steps: a) adding an acid to an aqueous solution of the compound of formula 1, including salts and hydrates thereof so as to obtain a slurry having a pH≤3; and b) filtering the slurry and at least one time washing the obtained precipitate with a liquid comprising water; and c) dissolving the precipitate obtained in step b) in water to obtain an aqueous solution; and d) filtering of the solution obtained in step c) over a nanofiltration membrane having a Molecular Weight Cut Off in the range from 150 to 500 and wherein optionally, between step c) and step d) the pH of the aqueous solution is adjusted to a pH value in the pH range as specified by the manufacturer of the nanofiltration membrane. A process for preparing a gadolinium complex of the purified compound of formula 1 is also disclosed. This gadolinium complex can be used for making a pharmaceutical composition as a contrast agent for magnetic resonance imaging.
Public/Granted literature
- US20170007726A1 PROCESS FOR PURIFYING 1,4,7,10-TETRA-AZACYCLODODECANE-1,4,7,10-TETRAACETIC ACID Public/Granted day:2017-01-12
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