The dressing has a pad for adhesive securement to a patient that includes a bubble for covering over a housing of a Huber needle assembly embedded in the patient. A slit is formed in the pad to allow passage of the tubing of the Huber needle assembly. In one embodiment, an insert of foam material is provided in the bubble to rigidify the bubble. A second section may also be provided for folding over the pad to encase the tubing, catheter and clamp of the Huber needle assembly.