A controller (20) for an advanced defibrillator (10) employs a therapy manager (30), a monitor manager (40), and a profile manager (50). In operation, the profile manager (50) manages a compilation of clinical usage profiles (60), each clinical usage profile (60) being derived from a different clinical usage of the advanced defibrillator (10) for the patient, and configures the therapy manager (30) and the monitor manager (40) responsive to a selection by a user of the advanced defibrillator (10) of one of the plurality of clinical usage profiles (60). Each clinical usage profile (60) includes a therapy profile (61) specifying a configuration of the therapy manager (30) for a delivery of an electric therapy to the patient. Each clinical usage profile (60) further includes a monitoring profile (62) specifying a configuration of the monitor manager (40) for a measuring of vital parameter(s) of the patient.