- Patent Title: Tissue engineering device and construction of vascularized dermis
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Application No.: US13766466Application Date: 2013-02-13
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Publication No.: US10195644B2Publication Date: 2019-02-05
- Inventor: Thomas Boland
- Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
- Applicant Address: US TX Austin
- Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
- Current Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
- Current Assignee Address: US TX Austin
- Agency: Norton Rose Fulbright US LLP
- Main IPC: B05D5/00
- IPC: B05D5/00 ; A61F2/10

Abstract:
An inkjet printing method, system, and computer-usable tangible storage device to print cells and biomaterials for three-dimensional cellular scaffolds and engineered skin grafts are disclosed. The process simultaneously deposits living cells, nutrients, growth factors, therapeutic drugs along with biomaterial scaffolds at the right time and location. This technology can also be used for the microvasculature fabrication using appropriate human microvascular endothelial cells and fibrin to form the microvasculature. When printing human microvascular endothelial cells in conjunction with the fibrin, the cells aligned themselves inside the channels and proliferated to form confluent linings. The 3D tubular structure was also found in the printed patterns. Simultaneously printing biological materials to form a three-dimensional cellular scaffold promotes human microvascular endothelial cell proliferation and microvasculature formation.
Public/Granted literature
- US20170087590A9 TISSUE ENGINEERING DEVICE AND CONSTRUCTION OF VASCULARIZED DERMIS Public/Granted day:2017-03-30
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