Invention Grant
![Hydrochloride salts of 8-[1-(3,5-bis-(trifluoromethyl)phenyl)-ethoxymethyl]-8-phenyl-1,7-diazaspiro[4,5]decan-2-one and preparation process therefor](/docs/US/2019-02-05/US10196394B2/abs.jpg.600x600.jpg)
- Patent Title: Hydrochloride salts of 8-[1-(3,5-bis-(trifluoromethyl)phenyl)-ethoxymethyl]-8-phenyl-1,7-diazaspiro[4,5]decan-2-one and preparation process therefor
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Application No.: US14683871Application Date: 2015-04-10
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Publication No.: US10196394B2Publication Date: 2019-02-05
- Inventor: Mengwei Hu , Sunil Paliwal , Neng-Yang Shih , Frank Bruno Guenter , Ingrid Mergelsberg
- Applicant: OPKO HEALTH, INC.
- Applicant Address: US FL Miami
- Assignee: OPKO Health, Inc.
- Current Assignee: OPKO Health, Inc.
- Current Assignee Address: US FL Miami
- Agency: Choate, Hall & Stewart LLP
- Agent Kristen C. Buteau; Michael A. Shinall
- Main IPC: A01N43/42
- IPC: A01N43/42 ; A61K31/44 ; C07D215/00 ; C07D217/00 ; C07D219/00 ; C07D221/00 ; C07D471/10 ; A61K31/435 ; A61K31/495 ; A61K45/06
![Hydrochloride salts of 8-[1-(3,5-bis-(trifluoromethyl)phenyl)-ethoxymethyl]-8-phenyl-1,7-diazaspiro[4,5]decan-2-one and preparation process therefor](/abs-image/US/2019/02/05/US10196394B2/abs.jpg.150x150.jpg)
Abstract:
Disclosed are hydrochloride and tosylate crystalline salt forms of (5S,8S)-8-[{(1R)-1-(3,5-Bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diazaspiro[4.5]decan-2-one, represented by Formula I and methods of preparing the same.
Public/Granted literature
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