Invention Grant
- Patent Title: Cell culture medium and process for controlling α-amidation and/or C-terminal amino acid cleavage of polypeptides
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Application No.: US14913312Application Date: 2014-08-20
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Publication No.: US10196601B2Publication Date: 2019-02-05
- Inventor: Tanja Ficko Trcek
- Applicant: LEK PHARMACEUTICALS D.D.
- Applicant Address: SK Ljubljana
- Assignee: LEK PHARMACEUTICALS D.D.
- Current Assignee: LEK PHARMACEUTICALS D.D.
- Current Assignee Address: SK Ljubljana
- Agency: Ballard Spahr LLP
- Priority: EP13181027 20130820
- International Application: PCT/EP2014/067762 WO 20140820
- International Announcement: WO2015/024977 WO 20150226
- Main IPC: C12N5/00
- IPC: C12N5/00 ; C07K16/24
Abstract:
The present invention is related to a cell culture medium for reducing the C-terminal heterogeneity of a polypeptide expressed in cell-culture, wherein the medium comprises at least one essential trace element in an effective amount, and to a cell culture process for reducing C-terminal heterogeneity of a protein, in which process an essential trace element is used.
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