Invention Grant
- Patent Title: Altered avian virus for in-ovo inoculation and methods of use thereof
-
Application No.: US15890575Application Date: 2018-02-07
-
Publication No.: US10196616B2Publication Date: 2019-02-05
- Inventor: Claudio L. Afonso , Valerie C. Marcano , Nany Stivalis Cardenas Garcia , Qingzhong Yu , Tonya L. Taylor
- Applicant: The United States of America, as represented by the Secretary of Agriculture , University of Georgia Research Foundation, Inc.
- Applicant Address: US DC Washington US GA Athens
- Assignee: The United States of America, as represented by the Secretary of Agriculture,University of Georgia Research Foundation, Inc.
- Current Assignee: The United States of America, as represented by the Secretary of Agriculture,University of Georgia Research Foundation, Inc.
- Current Assignee Address: US DC Washington US GA Athens
- Agent David L. Marks; John D. Fado; Gail E. Poulos
- Main IPC: C12N7/00
- IPC: C12N7/00 ; C07K14/54 ; A61K39/17 ; A61K39/12 ; A61P31/14 ; A61K39/00
Abstract:
An altered avian NDV that contains the coding sequence of avian interleukin-4 (IL-4), or a portion thereof, in the reverse orientation suppresses in-ovo IL-4 production via RNAi when administered to embryonic birds. An immunogenic composition containing this altered NDV is included in this invention. The altered avian NDV can, optionally contain a polynucleotide encoding a heterologous antigen from a heterologous avian pathogen and can produce said heterologous antigen in-ovo.
Public/Granted literature
- US20180230439A1 ALTERED AVIAN VIRUS FOR IN-OVO INOCULATION AND METHODS OF USE THEREOF Public/Granted day:2018-08-16
Information query
