Invention Grant
- Patent Title: Modified oligonucleotides for telomerase inhibition
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Application No.: US15194230Application Date: 2016-06-27
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Publication No.: US10196641B2Publication Date: 2019-02-05
- Inventor: Sergei Gryaznov , Krisztina Pongracz
- Applicant: Geron Corporation
- Applicant Address: US CA Menlo Park
- Assignee: Geron Corporation
- Current Assignee: Geron Corporation
- Current Assignee Address: US CA Menlo Park
- Agency: Bozicevic, Field & Francis LLP
- Agent Glenn J. Foulds
- Main IPC: C12N9/12
- IPC: C12N9/12 ; C12N15/11 ; C12N15/113 ; C12N5/00 ; C12N15/115 ; C07H21/02 ; C07H21/04 ; C07C233/18 ; A61K47/54
Abstract:
Compounds comprising an oligonucleotide moiety covalently linked to a lipid moiety are disclosed. The oligonucleotide moiety comprises a sequence that is complementary to the RNA component of human telomerase. The compounds inhibit telomerase activity in cells with a high potency and have superior cellular uptake characteristics.
Public/Granted literature
- US20170130225A1 MODIFIED OLIGONUCLEOTIDES FOR TELOMERASE INHIBITION Public/Granted day:2017-05-11
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