Invention Grant
- Patent Title: Chaperone-chaperone fusion polypeptides for reduction of interference and stabilization of immunoassays
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Application No.: US14640263Application Date: 2015-03-06
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Publication No.: US10197559B2Publication Date: 2019-02-05
- Inventor: Hartmut Duefel , Alexander Riedel , Peter Schaarschmidt , Urban Schmitt , Christian Scholz
- Applicant: Roche Diagnostics Operations, Inc.
- Applicant Address: US IN Indianapolis
- Assignee: Roche Diagnostics Operations, Inc.
- Current Assignee: Roche Diagnostics Operations, Inc.
- Current Assignee Address: US IN Indianapolis
- Agency: Stinson Leonard Street LLP
- Main IPC: C12N9/90
- IPC: C12N9/90 ; G01N33/53 ; C07K14/245
Abstract:
The invention concerns a fusion polypeptide including several molecules of folding helper polypeptides, including one multimerization domain, in particular Skp, and at least one molecule of SlyD or SlpA, wherein no further target polypeptide sequences are fused to the fusion polypeptide. The invention further concerns an immunoassay and the use of the fusion polypeptide in an immunoassay for reduction of interferences or minimizing false positive results or for stabilizing proteinaceous assay reagents. Further the invention concerns a reagent kit for use in an immunoassay comprising the fusion polypeptide.
Public/Granted literature
- US20170261498A1 CHAPERONE-CHAPERONE FUSION POLYPEPTIDES FOR REDUCTION OF INTERFERENCE AND STABILIZATION OF IMMUNOASSAYS Public/Granted day:2017-09-14
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