Techniques are described for facilitating interactions with device driver modules. In at least some situations, the techniques include managing interactions between device driver modules and other programs or hardware devices so as to minimize disruptions related to the device driver modules, including when changes to existing device driver modules are made. Such device driver module changes may have various forms and may occur for various reasons, including to install new versions of device driver modules or otherwise upgrade existing device driver modules. Furthermore, the interactions with device driver modules may be managed in various manners, including to allow changes to occur to a device driver module while that device driver module is in use on a computing system, but without causing other programs on the computing system to be restarted or to lose existing connections to the device driver module being changed.