A security system and method efficiently monitors and secures a computer to defend against malicious intrusions, and includes an in-band software monitor disposed within a kernel in communication with an operating system (OS) of the computer. The monitor intercepts system calls made from an MSR (Model Specific Register), to execute monitoring operations, and subsequently returns execution to the OS. An out-of-band hypervisor communicably coupled to the OS, has read shadow means for trapping read requests to the MSR, and write mask means for trapping write requests to the MSR. The hypervisor includes means for responding to the trapped read and write requests so that presence of the monitor is obscured.