Systems and methods for a workload optimized server for intelligent algorithm trading platforms. In an illustrative, non-limiting embodiment, an Information Handling System (IHS) may include a plurality of Central Processing Units (CPUs) and a control circuit coupled to the plurality of CPUs, the control circuit having a memory configured to store program instructions that, upon execution by the control logic, cause the IHS to: set a first number of enabled cores in a first CPU to operate with a first all-core turbo frequency, and set a second number of enabled cores in a second CPU to operate with a second all-core turbo frequency, where the first number of enabled cores is different from the second number of enabled cores, and where at least one of the first or second all core turbo frequencies is selected to cause the IHS to operate with reduced execution jitter.