The present disclosure provides D flip-flops and signal driving methods using D flip-flops thereof. An exemplary D flip-flop includes a pulse signal generating circuit configured to input a first clock signal, a first data signal, a second data signal and a third data signal and generate a clock pulse signal. The clock pulse signal responds a rising-edge and a falling-edge of the first clock signal. The pulse clock signal is a pulse signal when the first data signal is opposite to the second data signal. The D flip-flop also includes a latching circuit configured to sample and transfer the first data signal and a data signal opposite to the first data signal to be used as the second signal and a fourth data signal respectively when the clock signal is at the high level.