A measurement instrument and associated method: receive at a first input an aggressor signal (e.g., a supply voltage) from a device under test (DUT); capture samples of the aggressor signal; receive at a second input a victim signal from the DUT, wherein the received victim signal includes jitter induced thereon from the aggressor signal; capture samples of the received victim signal; apply the captured samples of the aggressor signal and the captured samples of the received victim signal to a predetermined model, which represents the jitter induced onto the received victim signal from the aggressor signal, to produce a system of equations; ascertain a plurality of unknown parameters in the predetermined model from the system of equations; and apply the predetermined model with the ascertained parameters to the captured samples of the aggressor signal to estimate the jitter induced onto the received victim signal from the aggressor signal.