Systems and methods are provided for adaptive control of pre-distortion during signal transmissions. While applying pre-distortion during processing of an input signal for transmission, feedback data may be generated based on a plurality of feedback signals, and adjustments to the pre-distortion may be applied to the pre-distortion based on the feedback data. Each of feedback signals corresponds to a particular processing stage performed during the processing of the input signal. Generating the feedback data comprises applying adjustments to the plurality of feedback signals based on a type and/or a source of at least one feedback signal, with the adjustments comprising one or more of: applying a gain to one of the plurality of feedback signals; applying a delay to one of the plurality of feedback signals; and modifying a first one of the plurality of feedback signals based on a second one of the plurality of feedback signals.