Embodiments of the present disclosure provide a method and a device for processing interference, wherein according to a first demodulation reference signal DMRS pilot symbol carried by a first subcarrier used by an uplink user equipment, an interference channel matrix of an uplink interference channel from the uplink user equipment to a D2D receiving end is measured, wherein the first subcarrier is a subcarrier shared by a D2D transmitting end and the uplink user equipment; a null space matrix of the uplink interference channel is calculated according to the interference channel matrix; and the signal received by the D2D receiving end via the first subcarrier is processed by using the null space matrix to eliminate an interference signal which comes from the uplink user equipment in the signal.