Invention Grant
- Patent Title: Polyprenylated phloroglucinol compounds as potent P-glycoprotein inducers
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Application No.: US15520063Application Date: 2015-07-20
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Publication No.: US10202326B2Publication Date: 2019-02-12
- Inventor: Sandip Bharate , Ajay Kumar , Jaideep Bharate , Prashant Joshi , Abubakar Wani , Ramesh Mudududdla , Rohit Sharma , Ram Vishwakarma
- Applicant: COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH
- Applicant Address: IN New Delhi
- Assignee: COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH
- Current Assignee: COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH
- Current Assignee Address: IN New Delhi
- Agency: Foley & Lardner LLP
- Priority: IN3004/DEL/2014 20141021
- International Application: PCT/IN2015/050069 WO 20150720
- International Announcement: WO2016/063296 WO 20160428
- Main IPC: C07C205/34
- IPC: C07C205/34 ; A61K31/122 ; C07C49/743 ; C07C49/84 ; C07D311/96
Abstract:
The present invention relates to the polyprenylated phloroglucinol compounds of formulae I and II. The present invention also provides synthesis and p-glycoprotein induction activity of the alkyl- and acyl-polyprenylated phloroglucinol compounds. Further, use of the compounds as p-glycoprotein inducers and methods of treatment of Alzheimer's disease using compounds of the invention are also provided.
Public/Granted literature
- US20170320802A1 POLYPRENYLATED PHLOROGLUCINOL COMPOUNDS AS POTENT P-GLYCOPROTEIN INDUCERS Public/Granted day:2017-11-09
Information query
