Invention Grant
- Patent Title: IL-15 mutant polypeptides as IL-15 antagonists and encoding nucleic acids
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Application No.: US14897344Application Date: 2014-06-27
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Publication No.: US10202433B2Publication Date: 2019-02-12
- Inventor: Yannick Jacques , Erwan Mortier , Agnes Quemener , Ariane Plet
- Applicant: INSERM (Institut National de la Sante et de la Recherche Medicale) , Universite de Nantes , Centre National de la Recherche Scientifique (CNRS) , Universite D'Angers
- Applicant Address: FR Paris FR Nantes FR Paris FR Angers
- Assignee: INSERM (Institut National de la Sante et de la Recherche Medicale),Universite de Nantes,Centre National de la Recherche Scientifique (CNRS),Universite D'Angers
- Current Assignee: INSERM (Institut National de la Sante et de la Recherche Medicale),Universite de Nantes,Centre National de la Recherche Scientifique (CNRS),Universite D'Angers
- Current Assignee Address: FR Paris FR Nantes FR Paris FR Angers
- Agency: Whitham & Cook, P.C.
- Priority: EP13305896 20130627
- International Application: PCT/EP2014/063637 WO 20140627
- International Announcement: WO2014/207173 WO 20141231
- Main IPC: C07K14/54
- IPC: C07K14/54 ; A61K38/00
Abstract:
The present relates to interleukin 15 (IL-15) antagonists and uses thereof, in particular for the treatment of autoimmune diseases and inflammatory diseases. In particular, the present invention relates to an IL-15 mutant polypeptide having the amino acid sequence as set forth in SEQ ID NO:1 wherein the leucine residue at position 45 is substituted by an aspartic acid residue, the asparagines residue at position 65 is substituted by a lysine residue and the leucine residue at position 69 is substituted by an arginine residue.
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