Invention Grant
- Patent Title: Vulcanisaetal phosphotriesterase-like lactonases (PLL) having enhanced properties and the uses thereof
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Application No.: US14905157Application Date: 2014-07-31
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Publication No.: US10202587B2Publication Date: 2019-02-12
- Inventor: Eric Chabriere , Mikael Elias , Julien Hiblot , Didier Raoult
- Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , UNIVERSITE D'AIX-MARSEILLE
- Applicant Address: FR Paris FR Marseilles
- Assignee: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE,UNIVERSITE D'AIX-MARSEILLE
- Current Assignee: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE,UNIVERSITE D'AIX-MARSEILLE
- Current Assignee Address: FR Paris FR Marseilles
- Agency: Young & Thompson
- Priority: EP13306109 20130731
- International Application: PCT/EP2014/066563 WO 20140731
- International Announcement: WO2015/014971 WO 20150205
- Main IPC: A62D3/02
- IPC: A62D3/02 ; C12N9/16 ; C11D3/386 ; A61K38/46 ; C11D3/48 ; C12N9/18 ; A62D101/02 ; A62D101/04 ; A62D101/26
Abstract:
Provided is a mutated hyperthermophilic PTE having a lactonase activity derived from a hyperthermophilic phosphotriesterase corresponding to the consensus sequence of SEQ ID NO: 1, the mutated PTE including the at least one mutation chosen amongst 55 putative positions and the mutated PTE having enhanced properties. Also provided are compositions including the mutated hyperthermophilic PTE and the uses thereof, notably as bioscavenger of organophosphate compounds or as quorum quencher of the bacteria using lactones to communicate.
Public/Granted literature
- US20160237413A1 VULCANISAETAL PHOSPHOTRIESTERASE-LIKE LACTONASES (PLL) HAVING ENHANCED PROPERTIES AND THE USES THEREOF Public/Granted day:2016-08-18
Information query
