Exemplary systems and methods for inhibiting backend access to an integrated circuit are provided including latch-up circuits triggered by photons, electrons, and ions to create catastrophic failures in integrated circuits. Exemplary systems include latch-up circuits with floating gate bit cells which, when triggered, close the latch-up circuits so that the latch-up circuits can amplify current in a positive feedback loop to create a short circuit to inhibit unauthorized individuals from probing or modifying an integrated circuit.