Invention Grant
- Patent Title: Androgen receptor variants and methods for making and using
-
Application No.: US14438399Application Date: 2013-10-25
-
Publication No.: US10206911B2Publication Date: 2019-02-19
- Inventor: Minna D. Balbas , Charles L. Sawyers , Philip Watson
- Applicant: MEMORIAL SLOAN-KETTERING CANCER CENTER
- Applicant Address: US NY New York
- Assignee: Memorial Sloan-Kettering Cancer Center
- Current Assignee: Memorial Sloan-Kettering Cancer Center
- Current Assignee Address: US NY New York
- Agency: Choate, Hall & Stewart LLP
- Agent Brenda Herschbach Jarrell
- International Application: PCT/US2013/066982 WO 20131025
- International Announcement: WO2014/066864 WO 20140501
- Main IPC: G01N33/53
- IPC: G01N33/53 ; A61K31/4439 ; C12Q1/6886 ; A61K31/4166 ; A61K49/00 ; C07K14/705 ; C07K16/28 ; C12N15/113 ; G01N33/50
Abstract:
The present invention encompasses the recognition that an F876L mutation of the androgen receptor (AR) gene confers resistance to the antiandrogens enzalutamide (MDV3100) and ARN-509 and is associated with incidence and/or risk of castration resistant prostate cancer (CRPC). The present invention also provides other AR polypeptide sequences associated with increased incidence and/or risk of CRPC. The present invention also provides screening methods for identification and/or characterization of novel AR polypeptide sequences associated with increased incidence and/or risk of CRPC via exposure to antiandrogens and for identification and/or characterization of agents to treat and/or reduce risk of CRPC by virtue of their effect on AR transcriptional activation.
Public/Granted literature
- US20150265587A1 ANDROGEN RECEPTOR VARIANTS AND METHODS FOR MAKING AND USING Public/Granted day:2015-09-24
Information query
IPC分类:
