Invention Grant
- Patent Title: Small molecule inhibitors of EGFR and PI3K
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Application No.: US15536528Application Date: 2015-12-15
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Publication No.: US10206924B2Publication Date: 2019-02-19
- Inventor: Christopher Emil Whitehead , Judith S. Leopold
- Applicant: The Regents of the University of Michigan
- Applicant Address: US MI Ann Arbor
- Assignee: The Regents of the University of Michigan
- Current Assignee: The Regents of the University of Michigan
- Current Assignee Address: US MI Ann Arbor
- Agency: Casimir Jones, SC
- Agent Robert A. Goetz
- International Application: PCT/US2015/065827 WO 20151215
- International Announcement: WO2016/100347 WO 20160623
- Main IPC: A61K45/06
- IPC: A61K45/06 ; A61P35/04 ; A61K31/517 ; C07D401/04 ; C07D401/14 ; C07D403/04 ; C07D403/14 ; C07D413/14 ; C07D471/04 ; A61K31/4706 ; A61K31/4709 ; A61K31/5377
Abstract:
This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having a quinazoline structure or a quinoline structure which function as dual inhibitors of EGFR proteins and PI3K proteins, and their use as therapeutics for the treatment of cancer and other diseases.
Public/Granted literature
- US20170360788A1 SMALL MOLECULE INHIBITORS OF EGFR AND PI3K Public/Granted day:2017-12-21
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