A machine tool for machining workpieces, wherein the machine tool has a first spindle assembly and at least one second spindle assembly each having at least two working spindles which are arranged in a common spindle housing and on which in each case a machining tool for workpiece machining is arrangeable, wherein the machine tool has a workpiece holding device for holding workpieces for the purpose of workpiece machining by way of the machining tools, wherein the machine tool has a guide arrangement for the relative positioning of the workpiece holding device holding the workpieces and the first and the at least one second spindle assembly for workpiece machining.