Invention Grant
- Patent Title: Substituted tetrahydroisoquinoline compounds as factor XIa inhibitors
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Application No.: US15918195Application Date: 2018-03-12
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Publication No.: US10208021B2Publication Date: 2019-02-19
- Inventor: Michael J. Orwat , Donald J. P. Pinto , Leon M. Smith, II , Shefali Srivastava
- Applicant: BRISTOL-MYERS SQUIBB COMPANY
- Applicant Address: US NJ Princeton
- Assignee: Bristol-Myers Squibb Company
- Current Assignee: Bristol-Myers Squibb Company
- Current Assignee Address: US NJ Princeton
- Agent Hong Liu
- Main IPC: C07D401/14
- IPC: C07D401/14 ; C07D413/14 ; C07D217/26 ; C07D401/04 ; C07D401/10 ; C07D471/10 ; C07D487/04 ; C07D487/08 ; C07D487/10 ; C07D491/10 ; C07D491/113 ; A61K31/4725 ; A61K31/496 ; A61K31/5377 ; A61K31/541 ; A61K31/55 ; A61K31/551 ; C07D491/107 ; A61P7/02
Abstract:
The present invention provides compounds of Formula (I): or stereoisomers, pharmaceutically acceptable salts thereof, wherein all of the variables are as defined herein. These compounds are inhibitors of factor XIa and/or plasma kallikrein which may be used as medicaments.
Public/Granted literature
- US20180201603A1 SUBSTITUTED TETRAHYDROISOQUINOLINE COMPOUNDS AS FACTOR XIA INHIBITORS Public/Granted day:2018-07-19
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