Invention Grant
- Patent Title: Condensed tricyclic compounds as protein kinase inhibitors
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Application No.: US15755019Application Date: 2016-08-25
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Publication No.: US10208056B2Publication Date: 2019-02-19
- Inventor: Joaquín Pastor Fernández , Sonia Martínez González , Carmen Blanco-Aparicio , Ana Isabel Hernández Higueras , Cristina Ana Gómez De La Oliva , Virginia Rivero Buceta , Rosario Concepción Riesco Fagundo
- Applicant: FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)
- Applicant Address: ES Madrid
- Assignee: FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)
- Current Assignee: FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)
- Current Assignee Address: ES Madrid
- Agency: Merchant & Gould P.C.
- Priority: EP15382431 20150826
- International Application: PCT/GB2016/052641 WO 20160825
- International Announcement: WO2017/033019 WO 20170302
- Main IPC: C07D491/147
- IPC: C07D491/147 ; C07D491/16 ; C07D491/22 ; A61K45/06 ; A61K31/5377 ; A61K31/437 ; A61P35/00 ; A61K31/4545

Abstract:
There is provided compounds of formula I, wherein R1, R2, R3 R4, R5, R6, R7a and R7b have meanings given in the description, and pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of diseases in which inhibition of a protein or lipid kinase (e.g. CDK8 and/or Haspin kinase) is desired and/or required, and particularly in the treatment of cancer or a proliferative disease.
Public/Granted literature
- US20180244687A1 CONDENSED TRICYCLIC COMPOUNDS AS PROTEIN KINASE INHIBITORS Public/Granted day:2018-08-30
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