Invention Grant
- Patent Title: Inhibitors of the renal outer medullary potassium channel
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Application No.: US15323989Application Date: 2015-07-09
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Publication No.: US10208064B2Publication Date: 2019-02-19
- Inventor: Alexander Pasternak , Ian Davies , Fa-Xiang Ding , Jinlong Jiang , Shuzhi Dong , Xin Gu , Takao Suzuki , Joseph P. Vacca , Zhifa Pu , Shouning Xu
- Applicant: MERCK SHARP & DOHME CORP. , Alexander Pasternak , Ian Davies , Fa-Xiang Ding , Jinlong Jiang , Shuzhi Dong , Xin Gu , Takao Suzuki , Joseph P. Vacca , Zhifa Pu , Shouning Xu
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Agent Sarah Hooson; Catherine D. Fitch
- Priority: WOPCT/CN2014/082119 20140714
- International Application: PCT/US2015/039635 WO 20150709
- International Announcement: WO2016/010802 WO 20160121
- Main IPC: C07D513/10
- IPC: C07D513/10 ; C07D519/00 ; A61K45/06 ; A61K31/435 ; A61K31/4745 ; A61K31/4375
Abstract:
The present invention provides compounds of Formula (I) and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention.
Public/Granted literature
- US20170197989A1 INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL Public/Granted day:2017-07-13
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