Invention Grant
- Patent Title: Macrocycles as factor XIa inhibitors
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Application No.: US15879619Application Date: 2018-01-25
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Publication No.: US10208068B2Publication Date: 2019-02-19
- Inventor: Donald J. P. Pinto , James R. Corte , Wu Yang , William R. Ewing
- Applicant: BRISTOL-MYERS SQUIBB COMPANY
- Applicant Address: US NJ Princeton
- Assignee: Bristol-Myers Squibb Company
- Current Assignee: Bristol-Myers Squibb Company
- Current Assignee Address: US NJ Princeton
- Agent Hong Liu
- Main IPC: C07D471/08
- IPC: C07D471/08 ; C07D487/08 ; C07D498/08 ; C07D519/00 ; C07D471/06 ; C07D487/06 ; C07D498/06

Abstract:
The present invention provides compounds of Formula (Ia): or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof, wherein all the variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.
Public/Granted literature
- US20180148461A1 NOVEL MACROCYCLES AS FACTOR XIA INHIBITORS Public/Granted day:2018-05-31
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