- Patent Title: Highly potent acid alpha-glucosidase with enhanced carbohydrates
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Application No.: US15515808Application Date: 2015-09-30
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Publication No.: US10208299B2Publication Date: 2019-02-19
- Inventor: Russell Gotschall , Hung V. Do
- Applicant: Amicus Therapeutics, Inc.
- Applicant Address: US NJ Cranbury
- Assignee: Amicus Therapeutics, Inc.
- Current Assignee: Amicus Therapeutics, Inc.
- Current Assignee Address: US NJ Cranbury
- Agency: Finnegan, Henderson, Farrabow, Garrett & Dunner, LLP
- International Application: PCT/US2015/053252 WO 20150930
- International Announcement: WO2016/054231 WO 20160407
- Main IPC: C12N9/40
- IPC: C12N9/40 ; A61K38/00 ; A61P43/00 ; A61K48/00 ; C12N15/09
Abstract:
Recombinant human alpha glucosidase (rhGAA) composition derived from CHO cells that contains a more optimized glycan composition consisting of a higher amount of rhGAA containing N-glycans carrying mannose-6-phosphate (M6P) or bis-M6P than conventional rhGAAs, along with low amount of non-phosphorylated high mannose glycans, and low amount of terminal galactose on complex oligosaccharides. Compositions containing the rhGAA, and methods of use are described.
Public/Granted literature
- US20170298335A1 Highly Potent Acid Alpha-Glucosidase With Enhanced Carbohydrates Public/Granted day:2017-10-19
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