Invention Grant
- Patent Title: Predicting human developmental toxicity of pharmaceuticals using human stem-like cells and metabolomic ratios
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Application No.: US15848188Application Date: 2017-12-20
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Publication No.: US10209240B2Publication Date: 2019-02-19
- Inventor: Alan Smith , Paul West , Jessica Palmer
- Applicant: STEMINA BIOMARKER DISCOVERY, INC.
- Applicant Address: US WI Madison
- Assignee: Stemina Biomarker Discovery, Inc.
- Current Assignee: Stemina Biomarker Discovery, Inc.
- Current Assignee Address: US WI Madison
- Agency: Brown Rudnick LLP
- Agent Adam M. Schoen, Esq.
- Main IPC: G01N33/50
- IPC: G01N33/50 ; G01N33/68
Abstract:
This present invention provides rapid, reproducible, biomarker-based screening methods for the developmental toxicity testing of compounds. The methods are designed to identify the exposure level at which a test compound perturbs metabolism in a manner predictive of developmental toxicity. In particular, the perturbation of two metabolites, ornithine and cystine, is measured, wherein a ratio of the fold change in ornithine to the fold change in cystine of less than or equal to about 0.88 is indicative of the teratogenicity of a test compound.
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