A compilation system can apply a smoothness constraint to the arguments of a compute-bound function invoked in a software program, to ensure that the value(s) of one or more function arguments are within specified respective threshold(s) from selected nominal value(s). If the constraint is satisfied, the function invocation is replaced with an approximation thereof. The smoothness constraint may be determined for a range of value(s) of function argument(s) so as to determine a neighborhood within which the function can be replaced with an approximation thereof. The replacement of the function with an approximation thereof can facilitate simultaneous optimization of computation accuracy, performance, and energy/power consumption.