Described herein are front-end architectures that use switch-combining in a MIMO module to provide uplink carrier aggregation and simultaneous MIMO operations in a plurality of band combinations. The front-end architectures include a combination of low-band, mid-band, high-band, MIMO, and uplink carrier aggregation modules to provide the described functionality. To provide certain band combinations, one or more of the modules can implement switchplexing to provide the targeted functionality.