A method, apparatus, and device for managing binding information on the network side are provided. The method includes the following steps: an entity on a network side sends a Binding Revocation Indication (BRI) message to an entity which stores binding relations of mobile nodes (MNs), where the binding relation includes a mapping between a home of address (HoA) of an MN and plurality of care of addresses (CoAs) of the MN and the BRI message includes at least one CoA ID; and the entity which stores the binding relations of MNs deletes the corresponding binding relation of at least one CoA ID in the BRI message after receiving the BRI message from the entity on the network side. Thus, with the present invention, the network side can delete the binding relation between a specified CoA and an HoA in the case of plurality of CoAs, which makes it easier to maintain corresponding binding relations.