A laser probe with a replaceable optic fiber may include a reusable handle, a reusable housing tube, a reusable handle adapter, a reusable machine adapter, and a replaceable optic fiber. The handle adapter may interface with a proximal end of the handle. The machine adapter may interface with a surgical machine. The replaceable optic fiber may include an optic fiber having a first optic fiber end and a second optic fiber end, a first connector, and a second connector. The optic fiber may be disposed within the first connector and the second connector. The first connector may be temporarily fixed within the handle adapter and the second connector may be temporarily fixed within the machine adapter.