- Patent Title: Method of inhibiting apolipoprotein-E expression while increasing expression of at least one of LDL-receptor protein or AbcA1 protein comprising administering a small compound
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Application No.: US15285296Application Date: 2016-10-04
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Publication No.: US10214502B2Publication Date: 2019-02-26
- Inventor: Santanu Maitra , Jungsu Kim
- Applicant: California State University, Fresno , Mayo Foundation for Medical Education and Research
- Applicant Address: US MN Rochester US CA Fresno
- Assignee: Mayo Foundation for Medical Education and Research,California State University, Fresno
- Current Assignee: Mayo Foundation for Medical Education and Research,California State University, Fresno
- Current Assignee Address: US MN Rochester US CA Fresno
- Agency: Fish & Richardson P.C.
- Main IPC: C07D295/26
- IPC: C07D295/26 ; C07C233/65 ; C07D295/195 ; C07C311/16 ; C07D295/03 ; C07C211/30 ; A61K31/166 ; A61K31/5375 ; A61K31/40 ; A61K31/4453 ; A61K31/18 ; A61K31/137 ; A61K31/167 ; C07C233/75 ; C07C233/64 ; C07C311/21 ; C07C311/20
Abstract:
This invention offers an effective method of decreasing expression of apolipoprotein E and increasing expression of at least one of either LDL-receptor protein or AbcA1 protein including selecting mammalian cells expressing apoE and at least one of either LDL-receptor protein or AbcA1 protein, contacting the mammalian cell with an effective amount of a compound having general formula (I) or general formula (II) in an amount sufficient to decrease expression of the apoE and increase expression of at least one of the LDL-receptor protein or the AbcA1 protein in the mammalian cell.
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