Invention Grant
- Patent Title: Bicyclic heteroaryl amine compounds
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Application No.: US15521202Application Date: 2015-10-21
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Publication No.: US10214537B2Publication Date: 2019-02-26
- Inventor: Rajeev S. Bhide , Douglas G. Batt , Robert J. Cherney , Lyndon A. M. Cornelius , Qingjie Liu , David Marcoux , James Neels , Michael A. Poss , Zheming Ruan , Qing Shi , Anurag S. Srivastava , Lan-ying Qin , Joseph A. Tino , Scott Hunter Watterson
- Applicant: BRISTOL-MYERS SQUIBB COMPANY
- Applicant Address: US NJ Princeton
- Assignee: Bristol-Myers Squibb Company
- Current Assignee: Bristol-Myers Squibb Company
- Current Assignee Address: US NJ Princeton
- Agent Gary Greenblatt
- International Application: PCT/US2015/056576 WO 20151021
- International Announcement: WO2016/064957 WO 20160428
- Main IPC: C07D487/04
- IPC: C07D487/04 ; C07D491/08 ; A61K31/53 ; A61K31/541 ; A61P29/00

Abstract:
Disclosed are compounds of Formula (I) or a salt thereof; wherein: X is N or CH; Q1 is: (i) Cl, Br, I, —CN, —CH3, or —CF3; (ii) a 5-membered heteroaryl selected from pyrrolyl, pyrazolyl, imidazolyl, oxazolyl, thiazolyl, triazolyl, oxadiazolyl, and thiadiazolyl; (iii) a 6?membered heteroaryl selected from pyridinyl, pyridazinyl, and pyrimidinyl; or (iv) a bicyclic heteroaryl selected from indolyl, pyrrolopyridinyl, pyrazolopyridinyl and benzo[d]oxazolyl; wherein each of said 5-membered, 6-membered, and bicyclic heteroaryl is substituted with zero to 1 Ra and zero to 1 Rb; and R1, R2, R3, R4, R5, R6, Ra, and Rb are defined herein. Also disclosed are methods of using such compounds as modulators of PI3K, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing inflammatory and autoimmune diseases.
Public/Granted literature
- US20170355707A1 BICYCLIC HETEROARYL AMINE COMPOUNDS Public/Granted day:2017-12-14
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