A port opening edge shape for a port in a cylinder of an opposed-piston combustion engine is optimized for flow area, as well as for minimization of piston ring clipping. The port opening edge shape includes a top edge, a bottom edge, a first and second side edge connecting the top and bottom edge, and an apex in the top edge. The apex has the minimum radius of curvature of the port opening edge shape. A spline that defines the port opening edge shape can be calculated based upon a maximum height, a full width, an amount or degree of skew, and a minimum radius of curvature. A model can measure values for engine performance and determine which spline defines a port opening edge shape yields a desired engine performance.