Invention Grant
- Patent Title: Method to measure tissue texture using NMR spectroscopy to identify the chemical species of component textural elements in a targeted region of tissue
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Application No.: US16028768Application Date: 2018-07-06
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Publication No.: US10215827B2Publication Date: 2019-02-26
- Inventor: Ian Parker , David R. Chase , Timothy W. James , Kristin James
- Applicant: BIOPROTONICS, LLC
- Applicant Address: US CA Santa Ynez
- Assignee: BIOPROTONICS INC.
- Current Assignee: BIOPROTONICS INC.
- Current Assignee Address: US CA Santa Ynez
- Agent Felix L. Fischer
- Main IPC: G01R33/56
- IPC: G01R33/56 ; G01R33/48 ; G01R33/483 ; G01R33/561 ; G01R33/563 ; G06T7/00

Abstract:
A method for identifying the chemical species of various textural elements in a targeted region of tissue wherein a volume of interest (VOI) is selectively excited and a k-encode gradient pulse is applied to induce phase wrap to create a spatial encode for a specific k-value and orientation. The specific k-value is selected based on anticipated texture within the VOI. Multiple sequential samples of the NMR RF signal encoded with the specific k-value are recorded as signal data. The Fourier Transform of the acquired signal data is then taken, wherein for each k-encode, the signal recorded is indicative of the spatial frequency power density at that point in k-space. Each peak in the NMR spectrum is then evaluated, whereby the relative contribution to the texture of tissue in the VOI at a k-value for each chemical species is determined.
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