Systems and methods related to Downlink-Uplink Decoupling (DUDe) in mixed licensed and unlicensed carrier wireless system are disclosed. In some embodiments, a method of operating a wireless device comprises communicating with a first radio node that operates on a licensed carrier to obtain a set of time resources in which the wireless device is expected to be scheduled for uplink data transmission on the licensed carrier and/or a set of time resources in which the wireless device is expected to receive downlink control transmission on the licensed carrier. The method further comprises communicating with a second radio node that operates on an unlicensed carrier to obtain, based on the set(s) of time resources for the licensed carrier, a set of time resources in which the wireless device will not be scheduled for downlink reception on the unlicensed carrier and receiving a downlink transmission from the second radio node accordingly.