Invention Grant
- Patent Title: Genetically modified major histocompatibility complex mice
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Application No.: US15413785Application Date: 2017-01-24
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Publication No.: US10219493B2Publication Date: 2019-03-05
- Inventor: Lynn Macdonald , Andrew J. Murphy , Naxin Tu , Cagan Gurer , Vera Voronina , Sean Stevens
- Applicant: Regeneron Pharmaceuticals, Inc.
- Applicant Address: US NY Tarrytown
- Assignee: Regeneron Pharmaceuticals, Inc.
- Current Assignee: Regeneron Pharmaceuticals, Inc.
- Current Assignee Address: US NY Tarrytown
- Agency: FisherBroyles, LLP
- Agent Rita S. Wu; Margarita Zippin
- Main IPC: A01K67/027
- IPC: A01K67/027 ; C07H21/04 ; C12N15/00 ; C12P21/08 ; C07K14/74 ; C12N15/85
Abstract:
The invention provides genetically modified non-human animals that express a humanized MHC II protein (humanized MHC II α and β polypeptides), as well as embryos, cells, and tissues comprising the humanized MHC II protein. Also provided are constructs for and methods of making said genetically modified non-human animals. Methods of using the genetically modified non-human animals to study various aspects of the human immune system are provided.
Public/Granted literature
- US20170135329A1 GENETICALLY MODIFIED MAJOR HISTOCOMPATIBILITY COMPLEX MICE Public/Granted day:2017-05-18
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