A radiography device includes: a radiation emitting unit that irradiates a subject with radiation at a plurality of different incident angles; a radiographic image generation unit that receives the radiation passed through the subject and generates a radiographic image; a part-of-interest detection unit that detects a mutation site suspected as a lesion from the radiographic image obtained by irradiating the subject with the radiation at a predetermined incident angle; and a radiography device control unit that controls whether to perform each of the tomosynthesis imaging in which the radiographic image generation unit generates the radiographic image while the radiation emitting unit changes the incident angle of the radiation and two-dimensional radiography in which the radiation emitting unit is fixed to a predetermined incident angle and the radiographic image generation unit generates the radiographic image, on the basis of a detection result of the part-of-interest detection unit.