A compression device controller for use with a compression garment includes a pressurized fluid source (e.g., a pump), a manifold in fluid communication with the pressurized fluid source, a pressure sensor in communication with the manifold, at least two bladder ports, and at least two two-way valves. The pressure sensor is arranged to measure a signal representative of pressure in the manifold. Each bladder port is connectable in fluid communication to a respective inflatable bladder of the compression garment. Each two-way valve is in fluid communication with the manifold and with a respective bladder port. Each two-way valve is actuatable to control fluid communication between the manifold and the respective bladder port.