• Patent Title: Treatment and prevention of stroke and other neurological disorders
  • Application No.: US14911943
    Application Date: 2014-08-14
  • Publication No.: US10220008B2
    Publication Date: 2019-03-05
  • Inventor: Jeff Wade Hill
  • Applicant: STC.UNM
  • Applicant Address: US NM Albuquerque
  • Assignee: STC.UNM
  • Current Assignee: STC.UNM
  • Current Assignee Address: US NM Albuquerque
  • Agent Henry D. Coleman; R. Neil Sudol
  • International Application: PCT/US2014/051025 WO 20140814
  • International Announcement: WO2015/023830 WO 20150219
  • Main IPC: A61K31/138
  • IPC: A61K31/138 A61K9/00 A61K31/27 A61K31/325 A61K45/06 G01N33/50
Treatment and prevention of stroke and other neurological disorders
Abstract:
Using high-throughput screening, in an oxygen-glucose deprivation (OGD) model, isoxsuprine hydrochloride was identified as a potent neuroprotective compound. In an animal middle artery occlusion (MCAO) model of transient focal ischemia, isoxsuprine significantly reduced infarct volume compared to vehicle. The invention, therefore, provides methods of treatment and pharmaceutical compositions that are useful in the treatment and prevention of a wide-variety of ischemia-related injuries, including stroke.
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