Invention Grant
- Patent Title: Methods of modulating HVEM, BTLA and CD160 cis complex response or signaling activity with soluble light polypeptide sequences
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Application No.: US14175892Application Date: 2014-02-07
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Publication No.: US10220081B2Publication Date: 2019-03-05
- Inventor: Carl F. Ware , Timothy C. Cheung , Marcos Steinberg
- Applicant: LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY
- Applicant Address: US CA La Jolla
- Assignee: LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY
- Current Assignee: LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY
- Current Assignee Address: US CA La Jolla
- Agency: Pillsbury Winthrop Shaw Pittmann LLP
- Main IPC: A61K39/00
- IPC: A61K39/00 ; C07K16/28
Abstract:
The invention provides HVEM cis complexes which include, for example, HVEM/BTLA, HVEM/CD160 and HVEM/gD cis complexes. The invention provides ligands and agents that bind to HVEM cis complexes, such as antibodies. The invention further provides methods of use of the HVEM cis complexes, and the ligands and agents (e.g., LIGHT polypeptide sequence) that bind to the HVEM cis complexes.
Public/Granted literature
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