Invention Grant
- Patent Title: Synergistic co-administration of computationally optimized broadly reactive antigens for H1N1 influenza
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Application No.: US15537081Application Date: 2015-12-18
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Publication No.: US10220086B2Publication Date: 2019-03-05
- Inventor: Ted Milburn Ross , Tim Alefantis , Donald Martin Carter , Christopher Austin Darby , Harold Kleanthous
- Applicant: Oregon Health & Science University , Sanofi Pasteur, Inc.
- Applicant Address: US OR Portland US PA Swiftwater
- Assignee: OREGON HEALTH & SCIENCE UNIVERSITY,SANOFI PASTEUR, INC.
- Current Assignee: OREGON HEALTH & SCIENCE UNIVERSITY,SANOFI PASTEUR, INC.
- Current Assignee Address: US OR Portland US PA Swiftwater
- Agency: MH2 Technology Law Group, LLP
- International Application: PCT/US2015/066882 WO 20151218
- International Announcement: WO2016/100922 WO 20160623
- Main IPC: A61K39/00
- IPC: A61K39/00 ; A61K39/12 ; A61K39/145
Abstract:
The present invention provides co-administration (for example, immunogenic cocktail compositions and/or prime-boost regimens) of computationally optimized H1N1 influenza hemagglutinin (HA) polypeptides. Co-administration of the optimized H1N1 influenza hemagglutinin (HA) polypeptides facilitates synergistic neutralization of viral infection and provides for improved protective immunity (e.g., a broad reactive immune response) to diverse and multiple H1N1 influenza virus strains, including both seasonal and pandemic strains.
Public/Granted literature
- US20170368164A1 SYNERGISTIC CO-ADMINISTRATION OF COMPUTATIONALLY OPTIMIZED BROADLY REACTIVE ANTIGENS FOR H1N1 INFLUENZA Public/Granted day:2017-12-28
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