Invention Grant
- Patent Title: Variants of yeast NDI1 gene, and uses thereof in the treatment of disease associated with mitochondrial dysfunction
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Application No.: US14367004Application Date: 2012-12-21
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Publication No.: US10220102B2Publication Date: 2019-03-05
- Inventor: Gwyneth Jane Farrar , Sophia Millington-Ward , Naomi Chadderton , Mathew Alan Carrigan , Paul Kenna
- Applicant: THE PROVOST, FELLOWS, FOUNDATION SCHOLARS, AND THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH, NEAR DUBLIN
- Applicant Address: IE Dublin
- Assignee: THE PROVOST FELLOWS FOUNDATION SCHOLARS AND THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLD AND UNDIVIDED TRINITY OF QUEEN ELIZABETH, NEAR DUBLIN TRINITY COLLEGE DUBLIN
- Current Assignee: THE PROVOST FELLOWS FOUNDATION SCHOLARS AND THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLD AND UNDIVIDED TRINITY OF QUEEN ELIZABETH, NEAR DUBLIN TRINITY COLLEGE DUBLIN
- Current Assignee Address: IE Dublin
- Agency: Nixon Peabody LLP
- Agent David S. Resnick; Teresa A. Ptashka
- Priority: EP11194796 20111221
- International Application: PCT/EP2012/076697 WO 20121221
- International Announcement: WO2013/093029 WO 20130627
- Main IPC: C12N9/02
- IPC: C12N9/02 ; A61K48/00 ; C07K14/395
Abstract:
An isolated nucleic acid sequence encoding the yeast NDI1 protein of SEQ ID NO: 542 or a functional variant thereof is described. The nucleic acid sequence comprises at least 50 codons which are codon optimized compared with the sequence of yeast NDI1 gene of SEQ ID NO: 1.
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