Various embodiments described herein provide an apparatus system, and method for detecting and treating various neurological events or conditions such as epilepsy and migraine headaches which are associated with cortical spreading depression (CSD). Also, many embodiments provide an apparatus, system and method for delivery of a drug such as a loop diuretic to prevent or reduce the duration of a seizure or other event associated with CSD. The drug may delivered intra-cranially in a dose selected to produce a localized effect in the brain to prevent or reduce the duration of the seizure or other event while minimizing adverse peripheral effects such as diuresis or electrolyte loss.