The disclosure provides a centrifugal microfluidics control system and a method configuring the same. The system may comprise a centrifugal tube; a centrifugal unit for accommodating the centrifugal tube and providing a centrifugal force to the centrifugal tube; a control unit fixed in bottom of the centrifugal tube; and a microfluidic supporting unit coupled to the control unit in the centrifugal tube. The control unit may change an orientation of the microfluidic supporting unit to change a direction of the centrifugal force applied to the microfluidic supporting unit.